Myelodysplastic syndromes are cartilage bottom axis corpuscle disorders consistent in chaotic and abortive hematopoiesis (blood production) embodied by irreversible quantitative and qualitative defects in hematopoietic (blood-forming) cells. In a majority of cases, the advance of ache is abiding with gradually deepening cytopenias due to accelerating cartilage bottom failure. Approximately one-third of patients with MDS advance to AML aural months to a few years.
The myelodysplastic syndromes (MDS, aforetime accepted as "preleukemia") are a assorted accumulating of hematological altitude affiliated by abortive assembly (or dysplasia) of myeloid claret beef and accident of transformation to astute myelogenous leukemia (AML).[1] MDS has been begin in humans, bodies and dogs. Anemia astute abiding claret admixture is frequently present. Astronomer Carl Sagan, biographer Roald Dahl, applesauce saxophonist Michael Brecker and extra Nina Foch died of this condition.
Signs and symptoms
The average age at analysis of a MDS is amid 60 and 75 years; a few patients are adolescent than 50; MDS diagnoses are attenuate in children. Males are hardly added frequently afflicted than females. Signs and affection are all-embracing and about accompanying to the claret cytopenias:
* Anemia—chronic tiredness, conciseness of breath, algid sensation, sometimes chest pain
* Neutropenia (low neutrophil count) —increased susceptibility to infection
* Thrombocytopenia (low platelet count) —increased susceptibility to bleeding and ecchymosis (bruising), as able-bodied as subcutaneous hemorrhaging consistent in purpura or petechia[2]
Many individuals are asymptomatic, and claret cytopenia or added problems are articular as a allotment of a accepted claret count:
* neutropenia, anemia and thrombocytopenia (low corpuscle counts of white and red claret cells, and platelets, respectively);
* splenomegaly or rarely hepatomegaly;
* aberrant granules in cells, aberrant nuclear appearance and size; and/or
* chromosomal abnormalities, including chromosomal translocations and aberrant chromosome number.
Although there is some accident for developing astute myelogenous leukemia, about 50% of deaths action as a aftereffect of bleeding or infection. Leukemia that occurs as a aftereffect of myelodysplasia is awfully aggressive to treatment.
Other articles and science reports on Adult Stem Cells.
Check, E., Cardiologists take heart from stem-cell treatment success, Nature 428(6986):880, 29 April 2004: "Adult stem cells have long been viewed as less flexible than embryonic stem cells, which can divide to produce any cell type in the body. But recent studies of human cells suggest that adult stem cells can also turn into many cell types, including heart, brain and liver cells."
Terada, N. et al., Bone marrow cells adopt the phenotype of other cells by spontaneous cells fusion, Nature (416(6880):542–545, 4 April 2002.
Cohen, P., Stem cells could save sight, New Scientist 175:(2354):18, 3 August 2002.
Stem cells do their stuff for Parkinson’s patient, New Scientist 174(2338):5, 13 April 2002.
Randerson, J., Stem cells fix the damage, New Scientist 177(2377):14, 11 January 2003.
Pluchino, S. et al., Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis, Nature 422(6933):688–694, 17 April 2003.
Jochen Ringe et al., Stem cells for regenerative medicine: advances in the engineering of tissues and organs, Naturwissenschaften 89(8), August 2002.
About the Formulator of StemEnhance - Christian Drapeau
Mr. Drapeau, a foremost scientist in the study of Aphanizomenon flos-aquae, holds a Masters of Science degree in Neurology and Neurosurgery from the Montreal Neurological Institute, an affiliate of McGill University in Montreal, Quebec, Canada. He has been extensively involved in the study of nutrition, naturopathy, and various natural therapies.
Most significantly, Mr. Drapeau collaborated with many scientists affiliated with Harvard University, McGill University, the University of Illinois, Oregon State University, the University of New Mexico, and the University of Mississippi in the study of the effects of blue-green algae (Aphanizomenon flos-aquae) on human health. Mr. Drapeau continues his involvement in the clinical study of AFA.
Circulating stem cells can reach various organs and become cells of that organ, helping such organ regain and maintain optimal health. Recent studies have suggested that the number of circulating stem cells is a key factor; the higher the number of circulating stem cells the greater is the ability of the body at healing itself. What happens to stem cells if they do not reach a tissue? Stem cells released from the bone marrow that do not reach a tissue simply return to the bone marrow after some timeCheck, E., Cardiologists take heart from stem-cell treatment success, Nature 428(6986):880, 29 April 2004: "Adult stem cells have long been viewed as less flexible than embryonic stem cells, which can divide to produce any cell type in the body. But recent studies of human cells suggest that adult stem cells can also turn into many cell types, including heart, brain and liver cells."
Terada, N. et al., Bone marrow cells adopt the phenotype of other cells by spontaneous cells fusion, Nature (416(6880):542–545, 4 April 2002.
Cohen, P., Stem cells could save sight, New Scientist 175:(2354):18, 3 August 2002.
Stem cells do their stuff for Parkinson’s patient, New Scientist 174(2338):5, 13 April 2002.
Randerson, J., Stem cells fix the damage, New Scientist 177(2377):14, 11 January 2003.
Pluchino, S. et al., Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis, Nature 422(6933):688–694, 17 April 2003.
Jochen Ringe et al., Stem cells for regenerative medicine: advances in the engineering of tissues and organs, Naturwissenschaften 89(8), August 2002.
About the Formulator of StemEnhance - Christian Drapeau
Mr. Drapeau, a foremost scientist in the study of Aphanizomenon flos-aquae, holds a Masters of Science degree in Neurology and Neurosurgery from the Montreal Neurological Institute, an affiliate of McGill University in Montreal, Quebec, Canada. He has been extensively involved in the study of nutrition, naturopathy, and various natural therapies.
Most significantly, Mr. Drapeau collaborated with many scientists affiliated with Harvard University, McGill University, the University of Illinois, Oregon State University, the University of New Mexico, and the University of Mississippi in the study of the effects of blue-green algae (Aphanizomenon flos-aquae) on human health. Mr. Drapeau continues his involvement in the clinical study of AFA.
United States Patent Patent No.: 6,814,961 B1 Date of Patent: November 9, 2004 Subj: METHOD FOR ENHANCING STEM CELL PHYSIOLOGY Inventors: Gitte S. Jensen and Christian Drapeau
